Stability of BIS with Schnider or modified Marsh effect-site targeted infusions: As you like it, or much ado about nothing?

Keywords: target-controlled infusion, total intravenous anaesthesia, pharmacokinetics, pharmacodynamics, bispectral index, depth of anaesthesia


Although commercial target-controlled infusion (TCI) systems have been available since the late 1990s1 and have facilitated safe and accurate administration of propofol in more than 90 countries,2 there remain areas of uncertainty and controversy.3

Author Biographies

E Coetzee, University of Cape Town

Department of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital, University of Cape Town, South Africa

A R Absalom, University of Groningen

Department of Anaesthesiology, University of Groningen, University Medical Centre Groningen, The Netherlands