pKa and Ka (Acid dissociation constant)

Keywords: pKa, Ka, acid dissociation constant


pKa of a drug is the pH at which 50% of the drug is ionised and 50% is not ionised/unionised.1,2

The pKa is specific for each drug and these properties determine how a drug can be administered, the speed of absorption as well as speed of excretion by the kidneys.2

Author Biography

G Manjooran, University of the Witwatersrand

Department of Anaesthesia, University of the Witwatersrand, South Africa

FCA 1 Anaesthetic Refresher Course 2020