Histamine has at least twenty-three known physiological functions, including playing a prominent role in immunologically mediated inflammation. The structure and metabolism of histamine is discussed, together with the various types of histamine receptors. Histamine plays a role in anaphylaxis, mast cell activation syndromes and mastocytosis and these conditions are relevant to anaesthetic practice. The antihistamine drugs and the H2 receptors agonists are discussed with regard to their role in anaesthesia.
By submitting manuscripts to SAJAA, authors of original articles are assigning copyright to the SA Society of Anaesthesiologists. Authors may use their own work after publication without written permission, provided they acknowledge the original source. Individuals and academic institutions may freely copy and distribute articles published in SAJAA for educational and research purposes without obtaining permission.
The work is licensed under a Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License. The SAJAA does not hold itself responsible for statements made by the authors.