Drug interactions

Keywords: drug interactions, anaesthesia, pharmocokinetic, pharmacodynamic, pharmaceutical


Administration of multiple drugs within a short period of time is inevitable in anaesthesia practice, increasing the likelihood of drug interactions with each drug or with patients’ chronic medication. Drug interactions can be described as the pharmacological effect of one drug on another drug when administered simultaneously.1 The principles of these interactions may be divided into pharmaceutical, which relates to the physicochemical structure or pharmaceutical preparation of a drug; pharmacokinetic (PK), which relates to changes in drug handling in the body; or pharmacodynamic (PD) where drug activity is affected.2

Author Biography

Z Jooma, University of the Witwatersrand

Department of Anaesthesia, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, South Africa

FCA 1 Anaesthetic Refresher Course 2020