Phase I reactions

Keywords: Phase I reactions, drug metabolism, chemical reactions


Phase I reactions fall under the broad topic of drug metabolism. Metabolism describes the chemical reactions that change drugs into compounds that are easier to eliminate. The reactions are catalysed by enzymes and happen mostly in the liver, though some reactions take place in the gut wall, lungs and blood plasma.1 Drug metabolism is divided into two phases: Phases I and II. This talk will focus on phase I.

Author Biography

T J Dibetso, University of the Witwatersrand

Department of Anaesthesia, University of the Witwatersrand, South Africa

FCA 1 Anaesthetic Refresher Course 2020